abstract：:What is the topic of this review? We review the current literature on the neural reflex termed the 'inflammatory reflex' that inhibits an excessive release of inflammatory mediators in response to an immune challenge. What advances does it highlight? The original model proposed that the inflammatory reflex is a vago-v...

journal_title：Experimental physiology

authors： Martelli D,Farmer DG,Yao ST

更新日期：2016-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is lower body negative pressure a useful surrogate to study white blood cell responses to haemorrhage in humans? What is the main finding and its importance? We found that lower body negative pressure appears to be a useful surrogate to study the early white bloo...

journal_title：Experimental physiology

authors： van Helmond N,Johnson BD,Curry TB,Cap AP,Convertino VA,Joyner MJ

更新日期：2016-10-01 00:00:00

abstract：:What is the topic of this review? This article presents emerging evidence for heightened carotid body chemoreflex activity as a major driver of sympathetic activation and hypertension in sleep apnoea patients. What advances does it heighlight? This article discusses the recent advances on cellular, molecular and epige...

journal_title：Experimental physiology

authors： Prabhakar NR

更新日期：2016-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? To what extent focal abdominal aortic aneurysmal (AAA) disease is associated with systemic remodelling of the vascular tree remains unknown. The present study examined whether anatomical differences exist between distances of the intervisceral artery origins and ...

journal_title：Experimental physiology

authors： Bailey DM,Evans TG,Thomas KG,White RD,Twine CP,Lewis MH,Williams IM

更新日期：2016-08-01 00:00:00

abstract：:What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would sho...

journal_title：Experimental physiology

authors： Donnelly WT,Bartlett D Jr,Leiter JC

更新日期：2016-07-01 00:00:00

abstract：:What is the central question of this study? Neurocognitive functions can be enhanced by acute aerobic exercise, which could be associated with changes in serum brain-derived neurotrophic factor (BDNF) concentrations. We aimed to explore acute exercise-induced changes in BDNF concentrations, neuropsychological and neur...

journal_title：Experimental physiology

authors： Tsai CL,Pan CY,Chen FC,Wang CH,Chou FY

更新日期：2016-07-01 00:00:00

abstract：:What is the central question of this study? Myocardial ischaemia-reperfusion (I/R) injury causes interference in the systemic circulation and damages not only the heart but also several vital organs, including the brain. Recently, a novel peptide called humanin has been shown to exert potent neuroprotective effects. H...

journal_title：Experimental physiology

authors： Kumfu S,Charununtakorn ST,Jaiwongkam T,Chattipakorn N,Chattipakorn SC

更新日期：2016-06-01 00:00:00

abstract：:What is the central question of this study? Can a modern proportional assist ventilator (PAV) function sufficiently well to unload the respiratory muscles during exercise? What is the main finding and its importance? A PAV can be constructed with contemporary hardware and software and be used at all exercise intensiti...

journal_title：Experimental physiology

authors： Dominelli PB,Henderson WR,Sheel AW

更新日期：2016-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...

journal_title：Experimental physiology

authors： Takahashi M,Nakamoto T,Matsukawa K,Ishii K,Watanabe T,Sekikawa K,Hamada H

更新日期：2016-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

journal_title：Experimental physiology

authors： Aksentijević D,Lewis HR,Shattock MJ

更新日期：2016-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This brief review discusses potential sex differences in arterial function across the age span, with special emphasis on the effects of oestrogen and testosterone on the vascular endothelium. What advances does it highlight? We discuss the relationship between the impacts ...

journal_title：Experimental physiology

authors： Green DJ,Hopkins ND,Jones H,Thijssen DH,Eijsvogels TM,Yeap BB

更新日期：2016-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. What advances does it highlight? Physiological studies have recently ...

journal_title：Experimental physiology

authors： Wray S

更新日期：2015-12-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? We discuss tools available to access genome-wide data sets that harbour cell-specific, brain region-specific and tissue-specific information on exon usage for several species, including humans. In this Review, we demonstrate how to access this information in genome databas...

journal_title：Experimental physiology

authors： Lipscombe D,Pan JQ,Schorge S

更新日期：2015-12-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? Excitation-contraction coupling in fish hearts is maintained over a range of temperatures that would be cardioplegic to most mammals. Here, we review what is known about the fish cardiac ryanodine receptor, and consider how it may be regulated in a different manner from th...

journal_title：Experimental physiology

authors： Shiels HA,Sitsapesan R

更新日期：2015-12-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review is principally concerned with results from studies of the pulmonary vasculature in humans, particularly in relation to hypoxia and rare diseases that affect oxygen sensing. What advances does it highlight? This review highlights the degree to which the hypoxia-...

journal_title：Experimental physiology

authors： Frise MC,Robbins PA

更新日期：2015-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does baroreceptor unloading during passive hyperthermia contribute to increases in ventilation and decreases in end-tidal carbon dioxide during that exposure? What is the main finding and its importance? Hyperthermic hyperventilation is not mitigated by expanding...

journal_title：Experimental physiology

authors： Lucas RA,Pearson J,Schlader ZJ,Crandall CG

更新日期：2015-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Pregnancy requires a robust plasma volume expansion driven by renal sodium retention. In the late-pregnant kidney, the aldosterone-responsive epithelial Na(+) channel is increased, whereas the sodium-chloride cotransporter is decreased. Pendrin has been shown to ...

journal_title：Experimental physiology

authors： West CA,Verlander JW,Wall SM,Baylis C

更新日期：2015-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do obesity-specific factors affect skeletal muscle performance in older individuals? What is the main finding and its importance? Older obese women have a larger quadriceps femoris size but develop lower tension per unit of skeletal muscle than their normal-weigh...

journal_title：Experimental physiology

authors： Rastelli F,Capodaglio P,Orgiu S,Santovito C,Caramenti M,Cadioli M,Falini A,Rizzo G,Lafortuna CL

更新日期：2015-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Our previous study demonstrates that elevated orexin 2 receptor (OX2R) activity within the rostral ventrolateral medulla (RVLM) contributes to hypertension in spontaneously hypertensive rats (SHRs), and a lower OX2R protein level was detected in their RVLM. The p...

journal_title：Experimental physiology

authors： Lee YH,Tsai MC,Li TL,Dai YW,Huang SC,Hwang LL

更新日期：2015-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central question of this study was to investigate the interaction of mild exposures to O2 and CO2 on chemoreflex control of SNA and the modulation of lung volume and respiratory phase on this interaction. What is the main finding and its importance? We demons...

journal_title：Experimental physiology

authors： Jouett NP,Watenpaugh DE,Dunlap ME,Smith ML

更新日期：2015-09-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? The sympathetic control of renal sodium tubular reabsorption is dependent on activation of the intrarenal renin-angiotensin system and activation of the angiotensin II type 1 (AT1 ) receptor by angiotensin II. What advances does it highlight? Despite the fact that the inte...

journal_title：Experimental physiology

authors： Pontes RB,Girardi AC,Nishi EE,Campos RR,Bergamaschi CT

更新日期：2015-04-20 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review describes the role of renal nerves as the key carrier of signals from the kidneys to the CNS and vice versa; the brain and kidneys communicate through this carrier to maintain homeostasis in the body. What advances does it highlight? Whether renal or autonomic ...

journal_title：Experimental physiology

authors： Nishi EE,Bergamaschi CT,Campos RR

更新日期：2015-04-20 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly understood. What is the main finding and its importance? Using resistance exerci...

journal_title：Experimental physiology

authors： Stöhr EJ,Stembridge M,Esformes JI

更新日期：2015-04-20 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the ultrastructural changes of the caecal mucosa and the status of epithelial cellular apoptosis and oxidative reactions in lactating goats after prolonged feeding with a high-concentrate diet? What is the main finding and its importance? High-concentrat...

journal_title：Experimental physiology

authors： Tao S,Tian J,Cong R,Sun L,Duanmu Y,Dong H,Ni Y,Zhao R

更新日期：2015-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides benefits over a standard welfare scoring system for ...

journal_title：Experimental physiology

authors： Faller KM,McAndrew DJ,Schneider JE,Lygate CA

更新日期：2015-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary ad...

journal_title：Experimental physiology

authors： Mosca EV,Rousseau JP,Gulemetova R,Kinkead R,Wilson RJ

更新日期：2015-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article describes the contribution of oxidative stress and pro-inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia. What advances does it highlight? Chronic in...

journal_title：Experimental physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2015-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical studies suggest that obesity 'protects' against osteoporosis. However, these studies used only bone densitometry and assessed only one bone site, which is insufficient to enable conclusions to be drawn about the response of the whole skeleton. Furthermor...

journal_title：Experimental physiology

authors： Lacerda DR,Serakides R,de Melo Ocarino N,Ferreira AV,Moraes MM,Boeloni JN,Silva JF,de Oliveira MC,de Barcellos LA,Rodrigues LO,Soares DD

更新日期：2015-01-01 00:00:00

abstract：:Exercise performance in hypoxia may be limited by a critical reduction in cerebral and skeletal tissue oxygenation, although the underlying mechanisms remain unclear. We examined whether increased systemic free radical accumulation during hypoxia would be associated with elevated microvascular deoxygenation and reduce...

journal_title：Experimental physiology

authors： Woodside JD,Gutowski M,Fall L,James PE,McEneny J,Young IS,Ogoh S,Bailey DM

更新日期：2014-12-01 00:00:00

abstract：:In humans, skeletal muscle blood flow is regulated by an interaction between several locally formed vasodilators, including NO and prostaglandins. In plasma, ATP is a potent vasodilator that stimulates the formation of NO and prostaglandins and, very importantly, can offset local sympathetic vasoconstriction. Adenosin...

journal_title：Experimental physiology

authors： Mortensen SP,Saltin B

更新日期：2014-12-01 00:00:00

abstract：:Recent studies showed that progesterone stimulates the hypoxic ventilatory response and may reduce apnoea frequency in newborn rats, but so far we still do not know by what mechanisms and whether endogenous progesterone might contribute to respiratory control in neonates. We therefore determined the role of the nuclea...

journal_title：Experimental physiology

authors： Potvin C,Rossignol O,Uppari N,Dallongeville A,Bairam A,Joseph V

更新日期：2014-11-01 00:00:00

abstract：:The present study examined whether an increase in leg blood flow and oxygen delivery at the onset of intense exercise would speed the rate of rise in leg oxygen uptake. Nine healthy men (25 ± 1 years old, mean ± SEM) performed one-leg knee-extensor exercise (62 ± 3 W, 86 ± 3% of incremental test peak power) for 4 min ...

journal_title：Experimental physiology

authors： Nyberg M,Christensen PM,Mortensen SP,Hellsten Y,Bangsbo J

更新日期：2014-10-01 00:00:00

abstract：:Disrupting circadian rhythms in rodents perturbs glucose metabolism and increases adiposity. To determine whether these effects occur in a large diurnal animal, we assessed the impact of circadian rhythm disruption upon metabolic function in sheep. Adult ewes (n = 7) underwent 3 weeks of a control 12 h light-12 h dark...

journal_title：Experimental physiology

authors： Varcoe TJ,Gatford KL,Voultsios A,Salkeld MD,Boden MJ,Rattanatray L,Kennaway DJ

更新日期：2014-09-01 00:00:00

abstract：:After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety. Indeed, it is the modification of gut hormone secretion that is consid...

journal_title：Experimental physiology

authors： Parker HE,Gribble FM,Reimann F

更新日期：2014-09-01 00:00:00

abstract：:Methyl CpG binding protein-2 (MECP2) is a chromatin-remodelling factor with a dual role in gene expression. Evidence from patients carrying MECP2 mutations and from transgenic mouse models demonstrates that this protein is involved in the control of body weight. However, the mechanism for this has not been fully eluci...

journal_title：Experimental physiology

authors： Torres-Andrade R,Moldenhauer R,Gutierrez-Bertín N,Soto-Covasich J,Mancilla-Medina C,Ehrenfeld C,Kerr B

更新日期：2014-09-01 00:00:00

abstract：:Haemorrhagic shock (HS) and fluid resuscitation can lead to increased reactive oxygen species (ROS), contributing to ischaemia-reperfusion injury and organ damage. Ubiquinol is a potent antioxidant that decreases ROS. This study examined the effects of ubiquinol administered with fluid resuscitation following controll...

journal_title：Experimental physiology

authors： Bennetts P,Shen Q,Thimmesch AR,Diaz FJ,Clancy RL,Pierce JD

更新日期：2014-07-01 00:00:00

abstract：:We hypothesized that exercise performance is adjusted during repeated sprints in order not to surpass a critical threshold of peripheral fatigue. Twelve men randomly performed three experimental sessions on different days, i.e. one single 10 s all-out sprint and two trials of 10 × 10 s all-out sprints with 30 s of pas...

journal_title：Experimental physiology

authors： Hureau TJ,Olivier N,Millet GY,Meste O,Blain GM

更新日期：2014-07-01 00:00:00

abstract：:We compared the effect of age- and sex-related differences in haemodynamics, blood volume (BV) and left ventricular (LV) size and mass on resting muscle sympathetic nerve activity (MSNA) in healthy, normotensive adults. Twenty young men (19-47 years old) and 20 young women (21-46 years old) as well as 15 older men (62...

journal_title：Experimental physiology

authors： Best SA,Okada Y,Galbreath MM,Jarvis SS,Bivens TB,Adams-Huet B,Fu Q

更新日期：2014-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, with a prevalence of 8-12% during the reproductive years. In the present study, using prenatal exposure to a single dose of testosterone during the critical period of fetal development, we aimed to introduce an enhanced rat model ...

journal_title：Experimental physiology

authors： Tehrani FR,Noroozzadeh M,Zahediasl S,Piryaei A,Azizi F

更新日期：2014-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Calcium is an important second messenger in eccrine sweating; however, whether modulation of extracellular Ca(2+) and Ca(2+) entry has the capacity to modulate sweat rate in non-glabrous human skin has not been explored. What is the main finding and its importanc...

journal_title：Experimental physiology

authors： Metzler-Wilson K,Sammons DL,Ossim MA,Metzger NR,Jurovcik AJ,Krause BA,Wilson TE

更新日期：2014-02-01 00:00:00